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عضو جدید
Antibacterial peptides (APs), small molecules composed of less than fifty amino acid residues, are important components
of the innate immune system. APs are produced by almost all living organisms in a defense strategy against invading
pathogens. APs can be divided into many subtypes following different criteria: origin, size, structure, mechanism of action,
etc... Despite their great diversity, APs share properties such as their ability to fold into amphipathic conformations, their
affinity for phospholipids, their amphiphilic nature,… APs have been shown to kill bacteria rapidly by acting on disrupting
the bacterial membrane in a non-specific way. Depending on the nature of the AP, many different modes of action have
been proposed. Nowadays, APs are a potential replacement for antibiotics, as resistance among pathogenic bacteria is
increasing and has become a global and growing public health problem. Throughout this review, we will focus on natural
and synthesized cationic antibacterial peptides, which are likely to show antibiotics properties. We will present and discuss
their secondary structure, mechanism of action, potential targets and role as therapeutic agent
[FONT="] Christine Cézard, Viviane Silva-Pires, Catherine Mullié and Pascal Sonnet, "Antibacterial Peptides: A Review", pp 926-937 , 2011 [/FONT]
of the innate immune system. APs are produced by almost all living organisms in a defense strategy against invading
pathogens. APs can be divided into many subtypes following different criteria: origin, size, structure, mechanism of action,
etc... Despite their great diversity, APs share properties such as their ability to fold into amphipathic conformations, their
affinity for phospholipids, their amphiphilic nature,… APs have been shown to kill bacteria rapidly by acting on disrupting
the bacterial membrane in a non-specific way. Depending on the nature of the AP, many different modes of action have
been proposed. Nowadays, APs are a potential replacement for antibiotics, as resistance among pathogenic bacteria is
increasing and has become a global and growing public health problem. Throughout this review, we will focus on natural
and synthesized cationic antibacterial peptides, which are likely to show antibiotics properties. We will present and discuss
their secondary structure, mechanism of action, potential targets and role as therapeutic agent
[FONT="] Christine Cézard, Viviane Silva-Pires, Catherine Mullié and Pascal Sonnet, "Antibacterial Peptides: A Review", pp 926-937 , 2011 [/FONT]
